Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations
نویسندگان
چکیده
منابع مشابه
Antimalarial Potential of Neem Limonoids against Plasmodium Falciparum
Received 10th December, 2012 Received in revised form 20th, December, 2012 Accepted 5th January, 2013 Published online 31 January, 2013 Objective: The antiplasmodial activity of pure n e e m l i m o n o i d s (azadirachtin, salannin, deacetylgedunin, gedunin, 17-h ydroxyazadiradione and deacetylnimbin) was evaluated in vitro against the chloroquine resistant and-sensitive strains of P. falcipar...
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Chlorpheniramine, a histamine H1 receptor antagonist, was assayed for in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum K1 strain and chloroquine-resistant P. falciparum T9/94 clone, by measuring the 3H-hypoxanthine incorporation. Chlorphenirame inhibited P. falciparum K1 and T9/94 growth with IC50 values of 136.0+/-40.2 microM and 102.0+/-22.6 microM respectively...
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Studying drug resistance in Plasmodium falciparum requires accurate measurement of parasite response to a drug. Factors such as mixed infection of drug-resistant and -sensitive parasites can influence drug test outcome. Polymorphic DNA sequences are frequently used to detect mixed infections; infections with a single genotype or having a minor allele smaller than a subjectively selected cut-off...
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BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf (same strain as in the vaccine) controlled human malaria infection (CHMI) 3 weeks after 5 doses administered intravenously. The next step was to assess protective efficacy against heterologous Pf (different from Pf in the vaccine),...
متن کاملEffect of membrane filtration of antimalarial drug solutions on in vitro activity against Plasmodium falciparum.
Antimalarial activities of chloroquine, mefloquine, amodiaquine, and quinine in vitro against Plasmodium falciparum were diminished as a consequence of membrane filtration. Filtered drug solutions gave ID(50) values up to 25-fold greater than those of non-filtered (ethanol-sterilized) drug solutions. Loss of activity by filtration was overcome by increasing the drug concentration prior to filtr...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.41023